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Although sex-specific responses to caloric restriction have been previously described 68,69 the use of female animals was intentional and aimed at enhancing translational relevance, as the patient included in the clinical case was also female

demonstrated that the hypermethylation of the PRKY promoter (cg05163709, cg08045599, and cg05618150) showed high diagnostic accuracy in detecting PRAD at early stages (SE: 96.88%